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    HSP70 Mouse mAb
    EM1042
    規格: 價格:
    50μL ¥1280.00
    100μL ¥1980.00

    Overview

    Product name: HSP70 Mouse mAb
    Reactivity: Human, Rat, Mouse
    Alternative Names: Heat shock 70 kDa protein 1/2, heat shock 70kDa protein 1A, HSP70, HSP70 1, HSP70 1/HSP70 2, HSP70 1A, HSP70.1/HSP70.2, HSP70I, HSP72, HSPA1, HSPA1A, HSPA1B
    Source: Mouse
    Dilutions: WB 1:1,000-2,000 IF 1:100-200? IHC 1:200-500
    Immunogen: Synthetic Peptide
    Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
    Clonality: Monoclonal
    Isotype: IgG1
    Concentration: 1mg/mL
    Observed Band: 70kDa
    GeneID: 3303
    Human Swiss-Prot No: P0DMV8
    Cellular localization: Cytoplasm
    Background: The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms. The Hsp70s are an important part of the cell's machinery for protein folding, and help to protect cells from stress. Hsp70 is usually in an ATP bound state. Hsp70 by itself is characterized by a very weak ATPase activity, such that spontaneous hydrolysis will not occur for many minutes. As newly synthesized proteins emerge from the ribosomes, the substrate binding domain of Hsp70 recognizes sequences of hydrophobic amino acid residues, and interacts with them. This spontaneous interaction is reversible, and in the ATP bound state Hsp70 may relatively freely bind and release peptides. However, the presence of a peptide in the binding domain stimulates the ATPase activity of Hsp70, increasing its normally slow rate of ATP hydrolysis.
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