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    EGFR Mouse mAb
    EM1044
    規格: 價格:
    50μL ¥1280.00
    100μL ¥1980.00

    Overview

    Product name: EGFR Mouse mAb
    Reactivity: Human
    Alternative Names: Epidermal Growth Factor Receptor ;ErbB-1; ErbB1; ER1; ERB-B1; MENA; HER1; Erythroblastic Leukemia Viral(v-Erb-B)oncogene Homolog,Avian; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
    Source: Mouse
    Dilutions: WB 1:1,000 IF 1;100-200? IHC 1:200-500
    Immunogen: Synthetic Peptide
    Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
    Clonality: Monoclonal
    Isotype: IgG1
    Concentration: 1mg/mL
    Observed Band: 170kDa
    GeneID: 1956
    Human Swiss-Prot No: P00533
    Cellular localization: Secreted and Cell membrane. Endoplasmic reticulum membrane
    Background: The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascadesβ-Actin is one of six different actin isoforms that have been identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical properties. Therefore, Antibodies against β-Actin are useful as loading controls for Western Blotting. However it should be noted that levels of β-Actin may not be stable in certain cells. For example, expression of β-Actin in adipose tissue is very low and therefore β-Actin should not be used as loading control for these tissues.
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